Physical concepts nanotechnology and applications in the biomedical realm. Different approaches to nanotechnology: Fabrication and functionalization of metallic and semiconductor nanomaterials used in biomedical applications. Bioplasmonics: concept of plasmon, Mie theory, nanophotothermy and therapeutic applications. Optical nano-sensors: theory and application of plasmonics, biosensors based on surface plasmon resonance. Biomedical nanophotonics: quantum dots, laser nano-surgery. Biomedical nano-magnetism: properties of magnetic nanomaterials and applications in biodetection, imaging and therapy. Ethics and social impact of biomedical nanotechnologies.

Physical plasma is often termed the fourth state of matter. What makes plasma one of the most versatile tools of modern technology? Cold physical plasmas operating at room temperature are now in use in hospitals in the field of plasma medicine. This new research field has gained vast attention in recent years not only due to the success in plasma treatment of chronic wounds, but also due to the promising results of first studies of plasmas in cancer therapies.

An introduction into the physics of plasmas will be given: Where lie the extreme points of plasma? What is the range of naturally occurring and artificially produced plasmas? How are the respective plasma properties determined and what are the fundamentals of plasma physics? A closer look at plasma-surface and plasma-liquid-interaction, electron- and ion properties, as well as different plasma models will be taken.

The lecture course will focus on current and future plasma applications in life science and on interaction of plasmas with biological systems, ranging from material synthesis for implants to disinfection and sterilization of medical devices to therapeutic applications of cold physical plasmas. Many mechanisms that lay the foundation of plasma medicine have been identified in experiments but especially in targeted therapy, several hypotheses have yet to be proven. The lecture course presents the state-of-the-art in plasma-bio research at the frontiers of science combining physics and medicine.

Contact and Questions: Stephan.reuter@polymtl.cahttps://plasma.polymtl.ca

Introduction aux microsystèmes dédiés aux applications biologiques et aux laboratoires sur puce . Définition et intérêt des biomicrosystèmes, effets d'échelle. Techniques de microfabrication : microstructures en silicium, microstructures en polymère, prototypage rapide. Principes microfluidiques : mécanique des fluides dans une microstructure, microflux multiphasiques, diffusion. Laboratoires sur puce : dispositifs microfluidiques, système de détection sur puce, effets électrocinétiques. Puce ADN. Puce à protéines. Analyse extracellulaire sur puce : électrophysiologie, réseaux de microélectrodes, microphysiomètre. Analyse intracellulaire sur puce : technique patch-clamp, patch-clamp sur puce. Libération locale de médicaments. Conception d'un dispositif de biomicrosystèmes.